Disclaimer: SARMs are solely for use for analysis functions, as they’re non-FDA permitted compounds and thus might trigger opposed results. You probably have any questions or considerations, Dr. Touliatos is at the moment obtainable for consultations.
Selective androgen receptor modulators (SARMs) have gotten more and more widespread within the bodybuilding world, attributable to their anabolic and lipolytic results.
Nevertheless, there aren’t any official dosing or cycle protocols issued by pharmaceutical authorities. This is because of SARMs being not too long ago formulated substances, and thus are but to be permitted by the FDA.
This information will element the frequent dosages being utilized anecdotally amongst women and men for beauty functions.
First SARM Cycle
An individual’s first SARM cycle is usually an Ostarine-only cycle. This is because of Ostarine having notable results on physique composition (with average muscle-building and fat-burning), together with it being probably the most well-tolerated SARM.
Thus, Ostarine is thought to provide the least unwanted effects out of all SARMs, offering a optimistic reward-to-risk ratio.
Customers can anticipate to construct as much as 10lbs of muscle on Ostarine, while burning roughly 3% of subcutaneous physique fats.
- Week 1: 10mg/day
- Week 2: 15mg/day
- Week 3: 20mg/day
- Week 4: 20mg/day
- Week 5: 20mg/day
- Week 6: 20mg/day
- Week 7: 20mg/day
- Week 8: 20mg/day
The above dosages are frequent for newcomers throughout their first SARM cycle. 10mg/day and 15mg/day for the primary two weeks slowly introduces Ostarine to the physique, with the dosage growing to a average one in every of 20mg/day for the following 6 weeks.
Some people can take as much as 30mg/day of Ostarine; nevertheless, that is thought of a excessive dose and thus shouldn’t be utilized by novices.
Ladies sometimes take 5-10mg/day of Ostarine for 4-8 weeks.
Ostarine has a half-life of 24 hours, and thus it solely must be administered as soon as per day.
The above consumer took 20mg/day for 45 days.
He misplaced 3kg (7lbs), notably lowering his physique fats, while concurrently including important quantities of muscle hypertrophy and power.
Ostarine Facet Results
Ostarine’s unwanted effects are thought of gentle in distinction to different SARMs, thus it is not uncommon for customers to not expertise any apparent unwanted effects.
Nevertheless, Ostarine does have the facility to trigger hepatic irritation, ldl cholesterol alterations and testosterone suppression.
TUDCA supplementation (500mg/day) may be taken throughout an Ostarine cycle, to stop ALT (alanine transaminase) and AST (aspartate transaminase) ranges from rising excessively.
Moreover, 4g/day of fish oil, a weight loss plan wealthy in unsaturated fat and common cardiovascular train can inhibit elevations in blood stress.
A post-cycle remedy can be utilized upon cycle cessation to speed up HPTA (hypothalamic-pituitary-testicular axis) restoration. One efficient PCT protocol is 20mg/day of Nolvadex, taken for 4 weeks.
RAD 140 Cycle
RAD 140 (Testolone) is taken into account by many to be the finest SARM, attributable to it having distinctive results on muscle hypertrophy and power; with out affecting aromatization or inflicting excessively harsh unwanted effects.
RAD 140 customers can construct as much as 15lbs of lean muscle, while burning notable quantities of fats. Customers may also enhance their muscular power on compound lifts by 20-30%. RAD-140’s potent anabolic nature means it’s primarily labeled as a bulking SARM.
That is thought of to be the very best solo SARM cycle males can make the most of; nevertheless, it might not be optimum for newcomers, attributable to it being harsher than Ostarine. Thus, a RAD-140 cycle makes for an ideal follow-up cycle to Ostarine.
- Week 1: 10mg/day
- Week 2: 10mg/day
- Week 3: 10mg/day
- Week 4: 10mg/day
- Week 5: 10mg/day
- Week 6: 10mg/day
- Week 7: 10mg/day
- Week 8: 10mg/day
RAD-140 is usually taken in dosages of 10-20mg/day for 6-12 weeks. Nevertheless, anecdotally, there may be proof that optimum outcomes may be achieved at 10mg/day. Past this level, additional outcomes could also be minimal (while exacerbating unwanted effects).
Skilled customers who’ve constructed up a degree of tolerance to RAD-140, nevertheless, do generally enhance their dosage to 15-20mg/day.
RAD 140 has a half-life of 60 hours . Thus, each day dosing isn’t important for peak concentrations within the bloodstream. Nevertheless, the frequent apply for a lot of customers is to take RAD-140 as soon as per day, particularly because it was beforehand believed to own a half-life of 20 hours.
The above consumer took 10mg/day of RAD-140 for 7 weeks, contributing to a 6.2kg enhance in lean physique mass and a 2.8% discount in physique fats. He additionally didn’t expertise any discernible unwanted effects from his cycle, aside from elevated perspiration.
His power additionally improved by roughly 20% on the bench press, squat and deadlifts.
RAD 140 Facet Results
RAD 140 will replicate the identical unwanted effects as Ostarine, however with extra depth. Thus, liver enzymes will rise, endogenous testosterone will drop considerably and HDL ldl cholesterol will likely be negatively impacted.
Taking a conservative dosage (10mg/day) is an efficient methodology to mitigate the unwanted effects on RAD-140. Moreover, supplementing with 500mg/day of TUDCA and 4g/day of fish oil will scale back hepatotoxicity and cardiotoxicity.
Nolvadex will even be an efficient PCT remedy (20mg/day x 4 weeks), accelerating the complete restoration of the HPTA.
Hair loss or pimples vulgaris can generally be skilled by people genetically prone to androgenetic alopecia, or overstimulated sebaceous glands. These two unwanted effects are attainable attributable to RAD-140 not directly affecting pure 5 alpha-reductase ranges.
LGD-4033 (Ligandrol) is one other bulking SARM, comparable in efficiency to RAD-140. The overall consensus anecdotally is that LGD-4033 produces larger weight acquire than RAD-140, however each SARMs produce comparable quantities of muscle and power.
LGD-4033 is, nevertheless, barely much less widespread than RAD-140, attributable to it growing the physique’s pure aromatization ranges; thus growing estrogen. This contributes to extra water retention, probably obscuring muscle definition. Nevertheless, larger ranges of intracellular fluid could also be preferable to some customers striving for sheer mass within the low season over aesthetics.
LGD-4033 customers sometimes will acquire as much as 20lbs, with roughly 25% of this being water weight.
Some customers reply higher to LGD-4033 and a few to RAD-140, thus it’s advisable to experiment with every of those compounds.
- Week 1: 6mg/day
- Week 2: 6mg/day
- Week 3: 6mg/day
- Week 4: 6mg/day
- Week 5: 6mg/day
- Week 6: 6mg/day
- Week 7: 6mg/day
- Week 8: 6mg/day
Dosages of LGD-4033 can sometimes vary from 4-10mg/day, with 6mg/day being the most well-liked protocol.
LGD-4033 solely must be administered as soon as per day, with it possessing a half-life of 24-36 hours (2).
The above consumer skilled distinctive ends in muscle hypertrophy, power and subcutaneous fats loss. He ingested 10mg/day for 8 weeks (excessive dose), which contributed to him gaining 20lbs of fat-free mass.
Regardless of taking a excessive dose, this consumer didn’t report of any disagreeable unwanted effects, aside from an insignificant bout of pimples vulgaris. Curiously, he didn’t administer a post-cycle remedy, as he didn’t expertise any low testosterone signs.
LGD-4033 Facet Results
LGD-4033 will mimic the identical unwanted effects of RAD 140, to roughly the identical diploma. Thus, notable ldl cholesterol alterations, liver toxicity and testosterone suppression will happen.
Due to this fact, dietary supplements resembling fish oil (4g/day), TUDCA (500mg/day) and Nolvadex as a PCT (40mg/day) proceed to be vital.
Nevertheless, LGD-4033 is seldom troublesome for androgenic unwanted effects (resembling male sample baldness), attributable to it conserving 5 alpha-reductase ranges secure.
Nevertheless, aromatization ranges can enhance not directly, probably inflicting puffy nipples and water retention in customers genetically delicate to excessive estrogen.
Cardarine is a PPARD (peroxisome proliferator activated receptor delta) agonist; nevertheless, it’s often known as a SARM.
Cardarine’s major two advantages are fats discount and muscular endurance.
Customers can expertise as much as 40lbs of weight reduction from 8-12 week cycles, even on a conservative dosage. Analysis has additionally proven Cardarine to boost endurance by 68% in simply 3 weeks in rodent fashions .
Anecdotally, Cardarine’s fat-burning results are fairly exceptional, with it being one of the vital potent lipolytic compounds formulated. Cardarine decreases fats mass by considerably bettering insulin sensitivity, lipid steadiness and glucose tolerance. This consequently transitions the physique from beforehand burning glucose for power, to adipose tissue.
Scientific analysis additionally means that Cardarine has gentle anabolic properties , which can contribute to muscle retention when slicing.
- Week 1: 10mg/day
- Week 2: 10mg/day
- Week 3: 10mg/day
- Week 4: 10mg/day
- Week 5: 10mg/day
- Week 6: 10mg/day
- Week 7: 10mg/day
- Week 8: 10mg/day
Cardarine is usually taken in dosages of 10-20mg/day for 8-12 weeks. Nevertheless, there may be anecdotal proof that decrease dosages and shorter cycle durations can nonetheless yield optimum outcomes.
Cardarine has a half-life of 24 hours and thus may be taken as soon as per day for regular blood ranges.
The consumer above cycled Cardarine at 10mg/day throughout week 1, and 20mg/day throughout weeks 2-8. His weight dropped from 205lbs to 165lbs.
The above consumer cycled Cardarine for 4 weeks at 10mg/day, enabling him to cut back his weight by 20lbs. This instance exhibits that low dosages of Cardarine and quick cycles nonetheless stay very potent.
Cardarine Facet Results
Cardarine isn’t technically a SARM and thus it has differing unwanted effects. Cardarine doesn’t trigger impairment to the HPTA and thus endogenous testosterone ranges stay at a regular degree. Levels of cholesterol additionally is not going to deteriorate, however really enhance on Cardarine, making it a cardioprotective stacking choice with SARMs that scale back HDL (high-density lipoprotein).
Nevertheless, attributable to Cardarine being administered orally, it does have an opposed impact on ALT/AST enzymes. Anecdotally, this might not be problematic for many customers within the short-term; nevertheless, warning is required if stacking Cardarine with a number of hepatotoxic SARMs on a frequent foundation.
Analysis has proven Cardarine to be carcinogenic when utilized in excessive dosages (5mg/kg per day) for protracted durations of time in rodent fashions. Thus, if somebody has unknowingly skilled proliferation of cancerous tumors, Cardarine will exacerbate this situation.
The danger of Cardarine inducing tumors in commonplace dosages (and quick cycles) is unclear. Nevertheless, we’re conscious of quite a few women and men which are taking Cardarine efficiently with out malignancy. It will be affordable to counsel that the carcinogenic danger of Cardarine could also be depending on the person’s predisposition to most cancers, their dosage and length of use.
Stenabolic (SR9009) is a REV-ERB agonist, and thus not technically a SARM.
REV-ERB agonists work by modifying an individual’s physique clock. Thus, they’re formulated with the target of inducing wakefulness throughout sunlight hours.
Stenabolic improves glucose and lipid metabolism, growing a person’s basal metabolic charge. Stenabolic additionally has direct fat-burning properties, because it shifts the physique’s main power supply from glucose to fats shops.
Stenabolic is comparable in efficiency to Cardarine, making it a possible cancer-free various compound. Customers can anticipate distinctive fat-burning and considerably improved muscular endurance.
Most customers can anticipate a 5% lower in physique fats from Stenabolic, when administered appropriately.
Stenabolic has a really low organic availability when taken in capsule type, thus customers are unlikely to expertise any results. Probably the most optimum strategies to manage Stenabolic are by injecting it or taking it sublingually. Merely swallowing is not going to be sufficient for ample absorption of this compound.
Taking Stenabolic sublingually includes inserting the answer below the tongue and letting it sit for 10-15 seconds earlier than swallowing. This allows a quick and environment friendly entry into the bloodstream, attributable to it making contact with the mucus membrane and thus bypassing first-pass metabolism.
The next dosages are tailor-made for taking Stenabolic sublingually.
- Week 1: 3omg/day
- Week 2: 30mg/day
- Week 3: 30mg/day
- Week 4: 30mg/day
- Week 5: 30mg/day
- Week 6: 30mg/day
- Week 7: 30mg/day
- Week 8: 30mg/day
Typical Stenabolic dosages vary from 20-30mg/day.
As Stenabolic has a really quick half-life (4-6 hours), it needs to be taken 3x per day (10mg at breakfast, 10mg at lunch and 10mg at dinner).
The above consumer took 20mg/day of Stenabolic for 8 weeks, together with 15-20mg/day of RAD 140. He misplaced appreciable quantities of fats (5% in physique fats) and added roughly 8lbs of muscle tissue, while consuming in a 500-calorie deficit.
Stenabolic Facet Results
Stenabolic-users report of only a few unwanted effects; nevertheless, a brief stimulative impact to the central nervous system may be anticipated. Thus, delicate customers might expertise elevated sweating, attributable to larger epinephrine ranges.
Be aware: Ostarine may be stacked with Cardarine or Stenabolic for additional fats loss and muscle retention when slicing (Ostarine dosage: 20mg/day for 8 weeks).
RAD-140 / LGD-4033 / MK-677 Cycle
Intermediate customers who’ve already run a number of SARM cycles and need to maximize beneficial properties in muscle hypertrophy, might mix RAD-140, LGD-4033 and MK-677 concurrently.
MK-677 (Ibutamoren) is a development hormone secretagogue usually mixed with SARMs to boost anabolism and the discount of subcutaneous fats. Its muscle-building results are thought of stronger than its lipolytic properties, and thus it’s extra generally utilized in bulking cycles.
MK-677 by itself can add 6lbs of lean muscle tissue to first-time customers. When utilized with RAD-140 and LGD-4033, muscle hypertrophy and power will enhance considerably.
This stack isn’t appropriate for newcomers, however for intermediates who’ve already cycled LGD-4033 or RAD-140 with well-managed unwanted effects.
Such a stack will allow customers to proceed including muscle mass, after preliminary development spurts from a RAD-140-only cycle, or an LGD-4033-only cycle.
- Week 1-2: LGD-4033 (5mg/day) / RAD-140 (5mg/day) / MK-677 (10mg/day)
- Week 3-8: LGD-4033 (5mg/day) / RAD-140 (15mg/day) / MK-677 (20mg/day)
The above consumer cycled MK-677, RAD-140 and LGD-4033 collectively, inducing optimistic enhancements in muscle hypertrophy, thickness and power.
These outcomes are typical of a person who has already taken SARMs or anabolic steroids, and needs to take a potent bulking stack to beat a hypertrophy plateau.
RAD 140 / LGD-4033 / MK-677 Facet Results
This needs to be thought of a harsh SARM cycle, and thus levels of cholesterol will surge, in addition to ALT/AST enzymes, presenting important cardiac and hepatic toxicity. Customers will even turn out to be very suppressed post-cycle, requiring an aggressive PCT to recuperate endogenous testosterone.
The next is a really potent PCT protocol designed by Dr. Michael Scally:
- hCG – 2000 IU administered each different day for 20 days
- Tamoxifen (nolvadex) – 2 x 20mg for 45 days
- Clomiphene (clomid) – 2 x 50mg for 30 days
This trio of medicines have been utilized in medical trials to deal with hypogonadal males with 100% success inside 45 days.
MK-677 may also trigger enhance visceral fats ranges, inflicting a bloated look to the midsection. Visceral fats is the inner adipose tissue that surrounds the organs, which numerous anabolic steroids additionally enhance, inflicting a ‘steroid intestine’ impact.
MK-677 may also exacerbate blood stress, attributable to elevated blood sugar ranges, growing the chance of atherosclerosis. As RAD-140 and LGD-4033 will even spike blood stress, attributable to reductions in HDL ldl cholesterol; blood stress needs to be carefully monitored throughout this cycle.
How Lengthy to Wait Between SARM Cycles?
Relaxation time ought to at the very least equal the length of use. Thus, if a SARM cycle final 8 weeks, the person ought to relaxation for no less than 8 weeks. Nevertheless, extra importantly, an individual needs to be in optimum well being earlier than beginning any SARMs cycle.
Are The Outcomes Everlasting?
Anecdotally, fats loss outcomes can usually be maintained post-cycle, assuming the particular person eats upkeep energy or much less.
Muscle beneficial properties are predominantly maintained post-cycle if customers proceed lifting weights.
LGD-4033-users are more likely to lose roughly 20% of weight post-cycle, which may be attributed to water loss.
Endurance beneficial properties from Cardarine and Stenabolic can decline post-cycle; nevertheless, nearly all of the outcomes may be maintained with common cardiovascular train.